Tumor necrosis factor-alpha polymorphism and susceptibility to juvenile idiopathic arthritis
نویسندگان
چکیده
منابع مشابه
Tumor necrosis factor-alpha polymorphism and susceptibility to juvenile idiopathic arthritis
Background Juvenile idiopathic arthritis (JIA) is a complex, multifactorial and chronic inflammatory disease of unknown etiology with considerable variability in which tumor necrosis factor-alpha (TNF-α) plays an important role. Both genetic and environmental factors can contribute to a susceptibility to disease initiation as well as a severity of disease course. TNF-α polymorphisms may be an i...
متن کاملEvaluation of Tumor Necrosis Factor Alpha Polymorphism Frequencies in Endometriosis
Background The pro-inflammatory cytokine, tumor necrosis factor-alpha (TNF-α), is a pathogenic element for a number of disorders. Previous studies have reported that the -1031 T/C and -238 G/A polymorphisms in the promoter region of the TNF-α gene are important factors in reproductive-related disorders. One of the most common gynecological diseases of women during the reproductive years is endo...
متن کاملtumor necrosis factor-alpha polymorphism and susceptibility to multiple sclerosis in the iranian population
conclusions the current study adds evidence to the association of tnf-α gene polymorphism and ms in this southern south iranian population which is consistent with the genetic analysis of ms in europeans (games) project reports and these two alleles reported in this study may be one of the genetic risk factor for ms. furthermore, this data can be used to build the iranian gene bank for future s...
متن کاملTumor necrosis factor alpha promoter polymorphisms in patients with juvenile idiopathic arthritis.
OBJECTIVE To investigate the potential association of tumor necrosis factor-alpha (TNF) promoter alleles within subtypes of juvenile idiopathic arthritis (JIA) compared to healthy controls in a Caucasian population. METHODS TNF-alpha promoter polymorphisms at positions -163, -238, -244, -308, -376 were determined in 228 patients with JIA and 196 healthy individuals. Genomic DNA was isolated a...
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Genetically determined differences in immune responses to environmental agents may underlie susceptibility to many autoimmune and infectious diseases. Leprosy provides an example of a polarity in the type of immune response made to an infectious agent, and there is evidence that the major histocompatibility complex is genetically linked to leprosy type. It was found that HLA-DR2 is associated w...
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ژورنال
عنوان ژورنال: Pediatric Rheumatology
سال: 2008
ISSN: 1546-0096
DOI: 10.1186/1546-0096-6-s1-p6